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Gq protein (Gαq, or Gq/11) is a heterotrimeric G protein subunit that activates phospholipase C (PLC). PLC in turn hydrolyzes Phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3) signal transduction pathway. DAG acts as a second messenger that activates Protein Kinase C (PKC) and IP3 helps in phosphorylation of some proteins. == Function == Gq proteins are class of G proteins which work to activate phospholipase C (PLC), participating in a variety of cellular signaling pathways. The Gq protein works by activating PLC. PLC then cleaves a phospholipid. In the process, phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and only allow the passage of calcium to move through. This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.〔 : ''Further reading: Calcium function in vertebrates'' In addition, calcium and DAG together work to activate PKC, which goes on to phosphorylate other molecules, leading to altered cellular activity.〔 : ''Further reading: function of protein kinase C'' 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Gq alpha subunit」の詳細全文を読む スポンサード リンク
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